xCELLigence RTCA CardioECR - 心肌细胞收缩性和电活动
CardioECR 还具有电刺激功能，可通过电刺激促进 hiPSC 心肌细胞成熟。刺激后的 hiPSC 心肌细胞呈现出显著改善的细胞表型，可用于各种研究，包括药物安全性/毒性评估、药物开发和心脏疾病研究。
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Product Details
- 监测兴奋-收缩耦联和离子通道活性
- 生成与致心律失常活动高度相关的数据
- 使用刺激功能进行更为严格可控的分析
- 获得对药物作用机制更深入的了解
细胞阻抗技术说明
细胞阻抗分析的功能单元是一组嵌入微孔板底面的微金电极。当浸入导电溶液（如缓冲液或标准组织培养基）中时，在这些电极间施加电压会使电子离开负极、流经细胞或培养基，然后回到正极形成完整电回路。
Learn More- Application Notes
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Cardiotoxicity Assessment of Antiviral Drugs Using the Agilent xCELLigence RTCA CardioECR System
This study used the Agilent xCELLigence RTCA CardioECR system with human iPSC-derived cardiomyocytes (hiPSC-CMs) to evaluate cardiac safety/toxicity of antiviral drugs.
- Application Notes
- English
- 21 May 2024
- 1.55 MB
Multimodal Connected Workflow for Cardiotoxicity Assessment Using Human iPSC-Derived Cardiomyocytes
This application note demonstrates the feasibility and use of combining multiple cell-based in vitro assays from Agilent that use diverse analytical technologies to investigate the cardiac liability of drugs.
- Application Notes
- English
- 26 Sep 2022
- 1002.14 KB
Connected Workflow: Assessment of Inotropic Compounds in PacedCardiomyocytes Using Calcium Imaging
This app note demonstrates the feasibility of using a connected workflow to evaluate the effect of inotropic compounds on electrically paced human iPSC derived cardiomyocytes (hiPSC-CMs) through calcium imaging
- Application Notes
- English
- 06 Jun 2022
- 2.93 MB
Assessment of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Disease Models Using the Agilent xCELLigence CardioECR System
A demonstration of the use of the Agilent xCELLigence RTCA CardioECR system to compare functional profiles of contractility and electrophysiology between an PS-iPSC-CM disease model and its isogenic control.
- Application Notes
- English
- 10 Sep 2021
- 2.82 MB
Using the Agilent xCELLigence RTCA ePacer for Functional Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
This application note presents a method for improving human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) maturation using the Agilent xCELLigence RTCA ePacer system.
- Application Notes
- English
- 11 Feb 2021
- 5.39 MB
A Real-Time Impedance Analysis Instrument for Cardiac Safety and Toxicity Assessment
In this application note, the RTCA Cardio instrument is used with human stem cell-derived cardiomyocytes (iCell Cardiomyocytes) for assessment of the cardiac safety profile of leading compounds or drug candidates during drug development.
- Application Notes
- English
- 04 Dec 2020
- 2.01 MB
The Agilent xCELLigence RTCA CardioECR System: A Multiparametric Functional Analysis Instrument for Cardiac Safety and Toxicity Assessment
In this application note, we used the xCELLigence RTCA CardioECR system (CardioECR system) in conjunction with hiPS-CMs for the assessment of preclinical cardiac risks.
- Application Notes
- English
- 16 Jul 2020
- 4.82 MB
- Article Reprints
- Brochures
- Data Sheets
- User Manuals
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User Guide for iCell Cardiomyocytes Assay on an xCELLigence RTCA CardioECR System
A guide for using the xCELLigence RTCA CardioECR system to analyze iCell cardiomyocytes.
- User Manuals
- English
- 21 Aug 2020
- 148.23 KB
E-Plate Coating User Guide
A guide for coating E-Plates.
- User Manuals
- English
- 21 Aug 2020
- 120.50 KB
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