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xCELLigence RTCA Cardio - Cardiomyocyte Contractility
The xCELLigence RTCA Cardio instrument, which analyzes cells in an electronic 96-well microtiter plate format (E-Plate Cardio 96), is placed in a standard CO2 cell culture incubator and interfaces via a cable with analysis and control units that are housed outside the incubator. User friendly software allows for real-time control and monitoring of the instrument.
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Product Details
- Provides a high-throughput method for detecting functional cardiotoxicity effects on short- and long-term cardio beating activity and for general toxicity
- Correlates findings with arrhythmogenic activity
- Provides insight into compound mechanism of action
- Application Notes
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Cardiotoxicity Assessment of Antiviral Drugs Using the Agilent xCELLigence RTCA CardioECR System
This study used the Agilent xCELLigence RTCA CardioECR system with human iPSC-derived cardiomyocytes (hiPSC-CMs) to evaluate cardiac safety/toxicity of antiviral drugs.
- Application Notes
- English
- 21 May 2024
- 1.55 MB
Multimodal Connected Workflow for Cardiotoxicity Assessment Using Human iPSC-Derived Cardiomyocytes
This application note demonstrates the feasibility and use of combining multiple cell-based in vitro assays from Agilent that use diverse analytical technologies to investigate the cardiac liability of drugs.
- Application Notes
- English
- 26 Sep 2022
- 1002.14 KB
Connected Workflow: Assessment of Inotropic Compounds in PacedCardiomyocytes Using Calcium Imaging
This app note demonstrates the feasibility of using a connected workflow to evaluate the effect of inotropic compounds on electrically paced human iPSC derived cardiomyocytes (hiPSC-CMs) through calcium imaging
- Application Notes
- English
- 06 Jun 2022
- 2.93 MB
Assessment of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Disease Models Using the Agilent xCELLigence CardioECR System
A demonstration of the use of the Agilent xCELLigence RTCA CardioECR system to compare functional profiles of contractility and electrophysiology between an PS-iPSC-CM disease model and its isogenic control.
- Application Notes
- English
- 10 Sep 2021
- 2.82 MB
Using the Agilent xCELLigence RTCA ePacer for Functional Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
This application note presents a method for improving human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) maturation using the Agilent xCELLigence RTCA ePacer system.
- Application Notes
- English
- 11 Feb 2021
- 5.39 MB
A Real-Time Impedance Analysis Instrument for Cardiac Safety and Toxicity Assessment
In this application note, the RTCA Cardio instrument is used with human stem cell-derived cardiomyocytes (iCell Cardiomyocytes) for assessment of the cardiac safety profile of leading compounds or drug candidates during drug development.
- Application Notes
- English
- 04 Dec 2020
- 2.01 MB
The Agilent xCELLigence RTCA CardioECR System: A Multiparametric Functional Analysis Instrument for Cardiac Safety and Toxicity Assessment
In this application note, we used the xCELLigence RTCA CardioECR system (CardioECR system) in conjunction with hiPS-CMs for the assessment of preclinical cardiac risks.
- Application Notes
- English
- 16 Jul 2020
- 4.82 MB
- Brochures
- Data Sheets
- User Manuals
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E-Plate Coating User Guide
A guide for coating E-Plates.
- User Manuals
- English
- 21 Aug 2020
- 120.50 KB
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