Manuel Portero-Otin 博士

利用更好的营养实现健康老龄化

安捷伦很荣幸协助莱里达大学实验医学系的 Manuel Portero-Otin 博士研究开发预防年龄相关疾病的高营养食品。

Portero-Otin 博士的团队正使用靶向代谢组学方法评估特定饮食变化对健康的影响，将精心设计的食品与健康生活方式结合，为更健康地度过晚年提供了一种整体方法。

该研究有助于解决营养代谢组学所面临的两大重要挑战。首先，通过开发个性化分子解决方案，可以解释不同人之间不同的衰老速率（受遗传背景、生活方式等因素的影响）。其次，考虑到营养因子能够引起大量微妙的化学变化，通过全代谢组描述可取得进展。

莱里达大学
实验医学系
西班牙莱里达

Lipidomics reveals altered biosynthetic pathways of glycerophospholipids and cell signaling as biomarkers of the polycystic ovary syndrome.
Jové M, Pradas I, Naudí A, Rovira-Llopis S, Bañuls C, Rocha M, Portero-Otin M, Hernández-Mijares A, Victor VM, Pamplona R.
Oncotarget. 2017 Dec 17;9(4):4522-4536. doi: 10.18632/oncotarget.23393

Region-specific vulnerability to lipid peroxidation and evidence of neuronal mechanisms for polyunsaturated fatty acid biosynthesis in the healthy adult human central nervous system.
Naudí A, Cabré R, Dominguez-Gonzalez M, Ayala V, Jové M, Mota-Martorell N, Piñol-Ripoll G, Gil-Villar MP, Rué M, Portero-Otín M, Ferrer I, Pamplona R.
Biochim Biophys Acta. 2017 May;1862(5):485-495. doi: 10.1016/j.bbalip.2017

Tumour-microenvironmental blood flow determines a metabolomic signature identifying lysophospholipids and resolvin D as biomarkers in endometrial cancer patients.
Eritja N, Jové M, Fasmer KE, Gatius S, Portero-Otin M, Trovik J, Krakstad C, Sol J, Pamplona R, Haldorsen IS, Matias-Guiu X.
Oncotarget. 2017 Nov 20;8(65):109018-109026. doi: 10.18632/oncotarget.22558

Differential metabolic profiles associated to movement behaviour of stream-resident brown trout (Salmo trutta).
Oromi N, Jové M, Pascual-Pons M, Royo JL, Rocaspana R, Aparicio E, Pamplona R, Palau A, Sanuy D, Fibla J, Portero-Otin M.
PLoS One. 2017 Jul 27;12(7):e0181697

A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to Humans.
Jové M, Naudí A, Gambini J, Borras C, Cabré R, Portero-Otín M, Viña J, Pamplona R.
J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):30-37.