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Steven Gross 博士

确定信号通路


生物学一氧化氮研究的最前沿

威尔康奈尔医学院的 Steven Gross 博士与安捷伦科技公司合作研究一氧化氮 (NO) 相关的疾病、治疗手段和生物医学问题。

NO 是一种重要的细胞信号分子，可影响各种生理过程，包括血压、神经信号传导和宿主防御。Gross 博士致力于确定 NO 信号通路以开发相关疾病的治疗手段，并应用代谢组学方法解决生物医学问题。本研究致力于鉴别新型分子机制和靶标，更好地解析细胞中 NO 的合成和行为，包括辅助基因的影响。

药理学教授
质谱核心实验室主任
威尔康奈尔医学院
纽约州纽约市

代表性出版物

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology.
Nuriel T, Angulo SL, Khan U, Ashok A, Chen Q, Figueroa HY, Emrani S, Liu L, Herman M, Barrett G, Savage V, Buitrago L, Cepeda-Prado E, Fung C, Goldberg E, Gross SS, Hussaini SA, Moreno H, Small SA, Duff KE.
Nat Commun. 2017 Nov 13;8(1):1464. doi: 10.1038/s41467-017-01444-0.

Reversible methylation of m6Am in the 5' cap controls mRNA stability.
Mauer J, Luo X, Blanjoie A, Jiao X, Grozhik AV, Patil DP, Linder B, Pickering BF, Vasseur JJ, Chen Q, Gross SS, Elemento O, Debart F, Kiledjian M, Jaffrey SR.
Nature. 2017 Jan 19;541(7637):371-375. doi: 10.1038/nature21022

Metabolite profiling of whole murine embryos reveals metabolic perturbations associated with maternal valproate-induced neural tube closure defects.
Akimova D, Wlodarczyk BJ, Lin Y, Ross ME, Finnell RH, Chen Q, Gross SS.
Birth Defects Res. 2017 Jan 30;109(2):106-119

Metabolomics enables precision medicine: "A White Paper, Community Perspective".
Beger RD, Dunn W, Schmidt MA, Gross SS, Kirwan JA, Cascante M, Brennan L, Wishart DS, Oresic M, Hankemeier T, Broadhurst DI, Lane AN, Suhre K, Kastenmüller G, Sumner SJ, Thiele I, Fiehn O, Kaddurah-Daouk R; for “Precision Medicine and Pharmacometabolomics Task Group”-Metabolomics Society Initiative.
Metabolomics. 2016;12(10):149

Untargeted metabolite profiling reveals that nitric oxide bioynthesis is an endogenous modulator of carotenoid biosynthesis in Deinococcus radiodurans and is required for extreme ionizing radiation resistance.
Hansler A, Chen Q, Ma Y, Gross SS.
Arch Biochem Biophys. 2016 Jan 1;589:38-52. doi: 10.1016/j.abb.2015.10.010.

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