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Is OpenLab CDS supported with an LTSC version of Microsoft Windows?

OpenLab CDS is designed to operate with the Windows 10 Professional versions included with personal computers. Microsoft releases these versions semi-annually as the semi-annual service channel (SASC). Reference the FAQ - Can I upgrade to the newest version of Windows when it is released by Microsoft?
 
LTSC is the long term servicing channel as explained by Microsoft at Lifecycle FAQ - Windows and Windows 10 Enterprise LTSC. Each LTSC version is based on a specific SASC version. OpenLab CDS is supported on the LTSC versions that are equivalent to tested SASC versions. See notes below for known caveats and deployment considerations.
  • For OpenLab CDS version 2.8, Windows 10 Enterprise LTSC 2021 is supported.
  • For OpenLab CDS versions 2.5, 2.6, and 2.7, Windows 10 Enterprise LTSC 2019 and LTSC 2021 are supported.
Note the following limitations:
  • The OpenLab CDS installer cannot install .NET Framework 3.5 if it is detected as missing. You will need to add this from Control Panel, Turn Windows features on or off.
  • The System Preparation Tool will report the Windows version is incorrect. It will not block the installation.