6545XT AdvanceBio LC/Q-TOF
6545XT AdvanceBio LC/Q-TOF
Accurately profile major and minor proteoforms with time-of-flight technology, offering new levels of sensitivity and clarity to intact protein mass spectrometry. Easily dig deeper into peptide digests with the Iterative MS/MS mode of operation. The 6545XT AdvanceBio Q-TOF is the analytical cornerstone in a comprehensive set of tools designed for biopharma.
- Quadrupole Time of Flight LC/MS
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Product Details
- Get up and running fast with quick-start methods that include Agilent AdvanceBio LC columns for intact protein and peptide workflows
- Characterize both major and minor intact protein variations with an automated data workflow featuring MassHunter BioConfirm software
- Adapt your instrument to your needs with SWARM autotune to ensure optimum performance with no manual adjustment
- Large molecule tune option provides sub-nanogram detection levels for intact glycosylated monoclonal antibodies
- Be sure of your results with mass accuracies within 10 ppm for glycosylated intact proteins
- Dig deeper into your digested samples with the powerful iterative MS/MS feature
- Maximize your uptime with a system tested to perform through thousands of protein injections without degradation of performance
- Minimize maintenance delays with vent-free cleaning of entrance optics
- Integration of either MOBILion Systems’ MOBIE or e-MSion’s ExD cell is supported
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| MS/MS Mass Accuracy (negative) |
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| MS/MS Mass Accuracy (positive) |
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| Quad Resolution (FWHM) |
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| Quadrupole Isolation Mass Range |
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| Supported Software Add-Ons |
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| TOF Mass Range |
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| Ventless Maintenance |
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Additional technology and software capabilities for LC/Q-TOF
Agilent partners with innovators who provide technologies and software that expand the core capabilities of the LC/Q-TOF portfolio. Learn more about additional capabilities and visit the compatibility matrix to see which ones are offered for your LC/Q-TOF.
Learn More- Key Literature
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Flash Characterization of Antibodies via Microdroplet Reactions in an Unmodified Jet Stream Source
This application note demonstrates in-source reaction of mAb's for flash characterization on an Agilent 6545XT AdvanceBio LC/Q-TOF.
- Application Notes
- English
- 12 Oct 2023
- 1.95 MB
Comprehensive and Integrated Workflow for Oligonucleotide Sequence Confirmation by Agilent High-Resolution LC/Q-TOF
This application note demonstrates an oligonucleotide sequence confirmation workflow using Agilent BioConfirm software with an Agilent 1290 Infinity II LC and Agilent 6545XT AdvanceBio LC/Q-TOF.
- Application Notes
- English
- 02 Aug 2022
- 2.40 MB
- Application Notes
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- Flyers
- Posters
- Technical Overviews
- White Papers
Agilent Announces Cutting-Edge Advances in GC/MS and LC/Q-TOF Technology at ASMS 2024
Agilent is introducing two new products. The Agilent 7010D Triple Quadrupole GC/MS System (7010D GC/TQ) features the new HES 2.0 ion source, providing attogram-level sensitivity, unmatched robustness, and industry-leading uptime. The Agilent ExD Cell available for the 6545XT AdvanceBio LC/Q-TOF enhances peptide and protein characterization capabilities by adding electron capture dissociation (ECD).
- 06 Jun 2024
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Agilent University
Develop skills and improve lab productivity with a wide variety of learning options from Agilent Education.
- Support
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MassHunter Data Acquisition for LC/TOF and LC/Q-TOF Familiarization Guide
This guide teaches you how to use your MassHunter Data Acquisition for Agilent LC/TOF or LC/Q-TOF system.
- Familiarization Checklists
- English
- 13 Jul 2023
- 4.44 MB
MassHunter Workstation 11.0 for LC/TOF and LC/Q-TOF Installation Guide
This book provides instructions to install the MassHunter Workstation software in these configurations: • Workstation (standalone, no content management) • Networked Workstation (networked, with content management on separate server)
- Installation Guides
- English
- 13 Jul 2023
- 967.69 KB
MassHunter Networked Workstation Functional Design Specifications
This document contains the Functional Design Specifications for your Agilent MassHunter Networked Workstation system.
- Specifications
- English
- 17 Nov 2022
- 13.06 MB
- FAQs
- Quick Reference Guides
- Site Preparation Checklists
- Supplemental Information
- User Manuals