BIO-DIS Reciprocating Cylinder Apparatus
The Agilent BIO-DIS reciprocating cylinder apparatus (Apparatus 3) is designed to meet current USP Apparatus 3 and EP Reciprocating Cylinder specifications. It is typically used for testing dosage forms in an environment where the the pH/gastrointestinal changes that occur in the body are simulated.
The BIO-DIS is suited for extended and sustained release dosage forms. Capable of running unattended for up to six days, the BIO-DIS can store up to 15 programs and provide direct control over timepoints, agitation rate, sampling time points, movement between vessel rows, hold dip time, and drain time.
The BIO-DIS is suited for extended and sustained release dosage forms. Capable of running unattended for up to six days, the BIO-DIS can store up to 15 programs and provide direct control over timepoints, agitation rate, sampling time points, movement between vessel rows, hold dip time, and drain time.
Product Details
Features
- Biorelevant—simulate gastrointestinal conditions with simple programming that allows in vitro dissolution pH profiling with biorelevant agitation rates and retention times.
- Flexible—useful for release-rate testing of floating dosage forms, beads and chewables. Use one instrument to test and transport a variety of samples, saving valuable bench space. Samples are automatically transported from one medium to the next without operator intervention.
- Compliant—be confident knowing the BIO-DIS is compliant with the reciprocating cylinder apparatus, USP Apparatus 3, and EP harmonized specifications.
- Easily configured—select a standard volumetric reciprocating cylinder option or small and large volume configuration to meet testing needs for low dose or poorly soluble formulations. Other options include a double row instrument for increased testing throughput (the number of media changes is reduced in half with this option).
- Automated sampling—easily perform automated sampling by integrating the Agilent 850-DS dissolution sampling station.
- Reporting—the built-in report center printer provides hard-copy documentation of testing progress and conditions. A four-line digital display provides updated operation information as the test progresses.
- Software control—available through the 21 CFR compliant dissolution workstation software, which allows direct programming of the BIO-DIS and 850-DS dissolution sampling station along with various pumps and filter changer.
- Temperature control—maintain temperature with the standard heater/circulator. All parameters are controlled by the BIO-DIS and entered from the front panel keypad.
