PD-L1 IHC 22C3 pharmDx Testing for Esophageal Cancer
In esophageal cancer, PD-L1 testing with PD-L1 IHC 22C3 pharmDx (SK006) can help identify patients for treatment with KEYTRUDA1,2
- Worldwide, there were over 600,000 cases of esophageal cancer diagnosed in 20203 and, in Europe, this type of cancer caused more than 45,000 deaths the same year 4
- PD-L1 testing provides a direct assessment of PD-L1 expression, which is a biomarker for response to anti-PD-1 therapy in esophageal cancer1,2
- PD-L1 testing with PD-L1 IHC 22C3 pharmDx was used to assess PD-L1 expression in patients with locally advanced unresectable or metastatic esophageal cancer in the KEYNOTE-590 clinical trial1,2
The only PD-L1 assay used in the KEYTRUDA KEYNOTE-590 clinical trial1,2
PD-L1 IHC 22C3 pharmDx is CE-IVD–marked as the clinical trial‑proven companion diagnostic for KEYTRUDA
* Cisplatin and 5-FU
When confidence in a PD-L1 test is critical, the ONE you choose is crucial
- The ONE PD-L1 assay used in KEYTRUDA clinical trials1,2
- The ONE PD-L1 assay first launched with KEYTRUDA in every indication that requires PD-L1 testing1,2
- The ONE PD-L1 assay trusted worldwide to test hundreds of thousands of patients for KEYTRUDA5
KEYTRUDA is a registered trademark of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
References: 1. PD-L1 IHC 22C3 pharmDx [Instructions for Use]. Santa Clara, CA: Agilent Technologies, Inc.; 2021. 2. Keytruda [Summary of Product Characteristics]. European Medicines Agency; 2021. 3. World Health Organization. Global Cancer Observatory. http://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf (accessed April 27, 2022). 4. World Health Organization. Global Cancer Observatory. https://gco.iarc.fr/today/data/factsheets/populations/908-europe-fact-sheets.pdf (accessed April 27, 2022). 5. Data on file. Agilent Technologies, Inc.
For countries outside of the European Union, see the local KEYTRUDA product label for approved indications and expression cutoff values to guide therapy.
D69413_01