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PD-L1 IHC 22C3 pharmDx Testing for Esophageal Cancer

The ONE Leading Assay with KEYTRUDA, Available in Esophageal Cancer
PD-L1 is an essential biomarker in esophageal cancer

In esophageal cancer, PD-L1 testing with PD-L1 IHC 22C3 pharmDx (SK006) can help identify patients for treatment with KEYTRUDA1,2

  • Worldwide, there were over 600,000 cases of esophageal cancer diagnosed in 20203 and, in Europe, this type of cancer caused more than 45,000 deaths the same year 4
  • PD-L1 testing provides a direct assessment of PD-L1 expression, which is a biomarker for response to anti-PD-1 therapy in esophageal cancer1,2
  • PD-L1 testing with PD-L1 IHC 22C3 pharmDx was used to assess PD-L1 expression in patients with locally advanced unresectable or metastatic esophageal cancer in the KEYNOTE-590 clinical trial1,2
Learn more about
PD-L1 IHC 22C3 pharmDx:
PD-L1 IHC 22C3 pharmDx is the ONE assay used to assess PD-L1 status across KEYTRUDA clinical trials

The only PD-L1 assay used in the KEYTRUDA KEYNOTE-590 clinical trial1,2

PD-L1 IHC 22C3 pharmDx is CE-IVD–marked as the clinical trial‑proven companion diagnostic for KEYTRUDA

For clinically relevant PD-L1 results in esophageal cancer, use PD-L1 IHC pharmDx

* Cisplatin and 5-FU

KEYNOTE-590 Trial Data
PD-L1 IHC 22C3 pharmDx Esophageal Cancer Interpretation Manual PD-L1 IHC 22C3 pharmDx Esophageal Cancer Interpretation Manual Refer to the Esophageal Cancer Interpretation Manual to review validated scoring guidelines that can help identify patients for treatment with KEYTRUDA
Online Atlas of Stains for Esophageal Cancer: PD-L1 IHC 22C3 pharmDx PD-L1 IHC 22C3 pharmDx Esophageal Cancer Online Atlas of Stains Coming Soon

Use the Online Atlas of Stains for Esophageal Cancer to increase your familiarity with PD-L1 staining in esophageal cancer specimens
Pursue lab excellence with the leading PD-L1 assay for KEYTRUDA

When confidence in a PD-L1 test is critical, the ONE you choose is crucial

  • The ONE PD-L1 assay used in KEYTRUDA clinical trials1,2
  • The ONE PD-L1 assay first launched with KEYTRUDA in every indication that requires PD-L1 testing1,2
  • The ONE PD-L1 assay trusted worldwide to test hundreds of thousands of patients for KEYTRUDA5
Choose PD-L1 IHC 22C3 pharmDx - the ONE leading assay with KEYTRUDA

KEYTRUDA is a registered trademark of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA

References: 1. PD-L1 IHC 22C3 pharmDx [Instructions for Use]. Santa Clara, CA: Agilent Technologies, Inc.; 2021. 2. Keytruda [Summary of Product Characteristics]. European Medicines Agency; 2021. 3. World Health Organization. Global Cancer Observatory. http://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf (accessed April 27, 2022). 4. World Health Organization. Global Cancer Observatory. https://gco.iarc.fr/today/data/factsheets/populations/908-europe-fact-sheets.pdf (accessed April 27, 2022). 5. Data on file. Agilent Technologies, Inc.

For countries outside of the European Union, see the local KEYTRUDA product label for approved indications and expression cutoff values to guide therapy.

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Review the PD-L1 IHC 22C3 pharmDx Intended Use