MAGE-A4 IHC 1F9 pharmDx
MAGE-A4 IHC 1F9 pharmDx Advancing Immunotherapy Options
Melanoma-associated antigen 4 (MAGE-A4) belongs to the melanoma antigen gene (MAGE) family. These includes cancer-testis antigens (CTAs) that are expressed in several solid tumor cell types, including synovial sarcoma. In cancers, MAGE-A4 (and other MAGE-A proteins) can inhibit the function of the tumor suppressor p53, enabling tumorigenesis. The aberrant expression of MAGE-A4 in cancer cells makes it an attractive target for immunotherapies including T-cell therapy.
References
1. Weon, J. L.; Potts, P. R. The MAGE Protein Family and Cancer. Curr. Opin. Cell Biol. 2015, 37, 1-8. DOI: 10.1016/j.ceb.2015.08.002.
2. Mitchell, G.; Pollack, S. M.; Wagner, M. J. Targeting Cancer Testis Antigens in Synovial Sarcoma. J. Immunother. Cancer 2021, 9 (6), e002072. DOI: 10.1136/jitc-2020-002072.
3. Alsalloum, A.; Shevchenko, J. A.; Sennikov, S. The Melanoma-Associated Antigen Family A (MAGE-A): A Promising Target for Cancer Immunotherapy? Cancers 2023, 15 (6), 1779. DOI: 10.3390/cancers15061779
References
1. Weon, J. L.; Potts, P. R. The MAGE Protein Family and Cancer. Curr. Opin. Cell Biol. 2015, 37, 1-8. DOI: 10.1016/j.ceb.2015.08.002.
2. Mitchell, G.; Pollack, S. M.; Wagner, M. J. Targeting Cancer Testis Antigens in Synovial Sarcoma. J. Immunother. Cancer 2021, 9 (6), e002072. DOI: 10.1136/jitc-2020-002072.
3. Alsalloum, A.; Shevchenko, J. A.; Sennikov, S. The Melanoma-Associated Antigen Family A (MAGE-A): A Promising Target for Cancer Immunotherapy? Cancers 2023, 15 (6), 1779. DOI: 10.3390/cancers15061779