6230 LC/TOF with the 1290 Infinity II Bio LC System
6230B Time of Flight (TOF) LC/MS
The Agilent 6230B time-of-flight LC/MS (LC/TOF) system allows you to upgrade from nominal mass measurements to a high-resolution accurate mass (HRAM) system for vastly enhanced analytical capabilities. Simultaneous measurement of the full spectrum of mass-to-charge ratios up to 20,000 improves speed and facilitates greater sensitivity. The full mass spectrum scan of a TOF LC/MS ensures that all necessary information is captured to enable screening, identification of unknowns, advanced statistical analysis, and biomolecule characterization. High resolving power allows for the separation of complex mixtures and aids in the determination of elemental formulae.
The 6230B TOF LC/MS is fully compatible with Agilent Bio-inert HPLC systems making it an ideal tool for intact protein characterization, glycan, and oligonucleotide analysis. The high resolution and accurate mass enable detection and identification of Extractables and Leachables (E&L), and many other impurities and target compounds. Advanced and intuitive software tools like one-click SWARM autotune and WalkUp software allow anyone to routinely achieve reliable results. The 6230B TOF LC/MS MassHunter software suite is compliance ready.
The 6230B TOF LC/MS is fully compatible with Agilent Bio-inert HPLC systems making it an ideal tool for intact protein characterization, glycan, and oligonucleotide analysis. The high resolution and accurate mass enable detection and identification of Extractables and Leachables (E&L), and many other impurities and target compounds. Advanced and intuitive software tools like one-click SWARM autotune and WalkUp software allow anyone to routinely achieve reliable results. The 6230B TOF LC/MS MassHunter software suite is compliance ready.
- Time of Flight LC/MS
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Product Details
Features
- Reduce false positives with better than 1 ppm mass accuracy
- Ensure excellent data quality even for fast UHPLC peaks in high-throughput workflows with data acquisition rates up to 44 spectra/second
- Identify compounds based on accurate mass, isotopic abundance, and chemical composition using Find by Formula in MassHunter software
- Analyze monoclonal antibodies (mAb) with high mass accuracy and resolving power for glycoforms and truncation
- Characterize large biologic compounds with a broad mass range of up to 20,000 m/z
- Separate target compounds from interferences with high-resolution data
- Find impurities at extremely low concentrations, using Agilent Jet Stream technology with low picogram on-column sensitivity
- Identify trace-level target compounds in the presence of more abundant matrix compounds with up to five orders of in-spectrum dynamic range
- Reduce administrative tasks and risks while eliminating the need for LC/MS expertise with intuitive MassHunter Walkup software
- Perform untargeted screening with optional fragmentation data using in-source dissociation
- Reduce administrative tasks and risks while eliminating the need for LC/MS expertise with intuitive MassHunter WalkUp software
- Go beyond UHPLC separation with support for capillary electrophoresis, SFC, 2D-LC, and even GC-APCI chromatographic interfaces.
Specifications
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| MS Mass Accuracy (positive) |
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| Polarity Switching Duty Cycle |
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| TOF Mass Range |
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| TOF Mass Resolution (FWHM) |
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| Temperature Mass Stability |
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Technology
Additional technology and software capabilities for LC/Q-TOF
Agilent partners with innovators who provide technologies and software that expand the core capabilities of the LC/Q-TOF portfolio. Learn more about additional capabilities and visit the compatibility matrix to see which ones are offered for your LC/Q-TOF.
Learn MoreApplications
Literature
- Key Literature
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Analysis of Monoclonal Antibodies
Using Multiple Heart-cutting Hydrophobic Interaction/Reversed Phase 2D-LC/MS
- Application Notes
- English
- 03 Feb 2016
- 778.87 KB
Metabolomics Batch Data Analysis Workflow to Characterize Differential Metabolites in Bacteria
"This discovery metabolomics application uses Q-TOF LC/MS to identify and understand the biological and biochemical nature of bacterium.
- Application Notes
- English
- 28 Apr 2015
- 3.21 MB
Rapid and Accurate Forensics Analysis using High Resolution “All Ions MS/MS”
This application note describes the use of a new technique, “All Ions MS/MS”, to rapidly screen and identify drugs of forensic toxicological interest.
- Application Notes
- English
- 01 Mar 2018
- 2.11 MB
- Application Notes
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Support
- Support
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MassHunter Data Acquisition for LC/TOF and LC/Q-TOF Familiarization Guide
This guide teaches you how to use your MassHunter Data Acquisition for Agilent LC/TOF or LC/Q-TOF system.
- Familiarization Checklists
- English
- 13 Jul 2023
- 4.44 MB
MassHunter Workstation 11.0 for LC/TOF and LC/Q-TOF Installation Guide
This book provides instructions to install the MassHunter Workstation software in these configurations: • Workstation (standalone, no content management) • Networked Workstation (networked, with content management on separate server)
- Installation Guides
- English
- 13 Jul 2023
- 967.69 KB
MassHunter Networked Workstation Functional Design Specifications
This document contains the Functional Design Specifications for your Agilent MassHunter Networked Workstation system.
- Specifications
- English
- 17 Nov 2022
- 13.06 MB
- FAQs
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- Site Preparation Checklists
- Supplemental Information
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A step-by-step workflow review of peptide mapping using LC/MS
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