6560C ion mobility Q-TOF LC/MS system
6560 Ion Mobility LC/Q-TOF
The system features innovative electrodynamic ion funnel technology to dramatically improve sensitivity while maintaining an attractive low field drift tube design. This allows you to directly measure accurate collision cross sections (CCS) and preserve labile targets. Whether you are looking to create a more comprehensive profile of metabolomics samples, characterize complex polymeric mixtures, or understand structural changes in biomolecules, ion mobility mass spectrometry provides access to new information.
- Quadrupole Time of Flight LC/MS
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Product Details
- First-principle based collision cross-section measurement and accuracy without standards.
- Utmost separation capacity, combining UHPLC, ion mobility, and high resolution mass spectrometry.
- Better separation of complex isobaric classes such as lipids and glycans.
- In-depth characterization of structural conformations and isomeric compounds.
- Conservation of structural fidelity of molecules in the gas phase using the low-energy drift tube design.
- Multiplexing for substantially increased sensitivity and dynamic range, with enhancement of one order of magnitude.
- Ion mobility resolution of up to 200 in full spectra can be achieved via postprocessing with the Agilent high resolution demultiplexing ( HRdm 2.0) software.
- Collision-induced unfolding (CIU) for quantitative structural analysis of proteins includes in-source activation for induced fragmentation of molecules.
- Up to 5 Hz acquisition rate can be used without compromising resolution for UHPLC compatibility.
- Utilizes Agilent VacShield for vent-free capillary removal.
| In-spectra Dynamic Range |
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| Ion Mobility Resolution (FWHM) |
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| Ion Source |
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| MS Acquisition Rate |
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| MS Mass Accuracy (positive) |
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| MS Sensitivity (positive) |
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| MS/MS Acquisition Rate |
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| MS/MS Mass Accuracy (positive) |
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| Quad Resolution (FWHM) |
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| Quadrupole Isolation Mass Range |
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| Software Platform |
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| Supported Software Add-Ons |
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| TOF Mass Range |
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| TOF Mass Resolution (FWHM) |
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| Temperature Mass Stability |
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| Ventless Maintenance |
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Additional technology and software capabilities for LC/Q-TOF
Agilent partners with innovators who provide technologies and software that expand the core capabilities of the LC/Q-TOF portfolio. Learn more about additional capabilities and visit the compatibility matrix to see which ones are offered for your LC/Q-TOF.
Learn More- Application Notes
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Targeted Data Mining and Annotation of Untargeted High-Resolution Lipidomics Data
Application note documenting a curated, high confidence lipidomics workflow for LC/Q-TOF.
- Application Notes
- English
- 27 Aug 2024
- 2.18 MB
Exact Structure Identification of Isomeric N-Glycans by High-Resolution Ion Mobility LC/Q-TOF
This application note describes the assignment of exact structures of N-glycan released from glycoproteins of complex biological sample using ion mobility-mass spectrometry (IM-MS) exploiting unique arrival time distributions (ATDs) for each glycan.
- Application Notes
- English
- 22 Oct 2021
- 755.55 KB
Structural Analysis of the Multimers of Bovine Serum Albumin by Ion Mobility Mass Spectrometry
This application note presents the use of the Agilent 6560 ion mobility LC/Q-TOF to analyze the formation of multimers of bovine serum albumin (BSA) in various mobile phases.
- Application Notes
- English
- 03 Jan 2020
- 3.55 MB
Examining the Structural Influence of Site-Specific Phosphorylation by Ion Mobility Mass Spectrometry
An automated workflow for the analysis of protein phosphorylation from sample preparation with phosphopeptide enrichment to analysis by IMS.
- Application Notes
- English
- 03 Dec 2019
- 1.56 MB
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Agilent Wins Multiple 2022 Scientists' Choice Awards at ASMS
Based on votes from scientists around the world, the Agilent 6560C Ion Mobility LC/Q-TOF was awarded the Best New Spectroscopy Product of 2021. Additionally, Agilent won the Analytical Science Video Interview of the Year award for its customer video interview with Matt Campion from Airborne Honey, on Robust analysis for ensuring honey authenticity.
- 22 Jun 2022
Videos
Structural insights into Biomolecules by Ion Mobility MS
Gain insight into protein structural changes via Collision Induced Unfolding (CIU) and separation of in-class isomers via high-resolution demultiplexing (HRdm).
Development of a New Uniform-Field Ion Mobility Q-TOF MS
How the development of a new ion mobility Q-TOF can increase the peak capacity and separation resolution to facilitate high-throughput analysis of biomolecular mixtures.
- Support
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MassHunter Data Acquisition for LC/TOF and LC/Q-TOF Familiarization Guide
This guide teaches you how to use your MassHunter Data Acquisition for Agilent LC/TOF or LC/Q-TOF system.
- Familiarization Checklists
- English
- 13 Jul 2023
- 4.44 MB
MassHunter Workstation 11.0 for LC/TOF and LC/Q-TOF Installation Guide
This book provides instructions to install the MassHunter Workstation software in these configurations: • Workstation (standalone, no content management) • Networked Workstation (networked, with content management on separate server)
- Installation Guides
- English
- 13 Jul 2023
- 967.69 KB
MassHunter Networked Workstation Functional Design Specifications
This document contains the Functional Design Specifications for your Agilent MassHunter Networked Workstation system.
- Specifications
- English
- 17 Nov 2022
- 13.06 MB
- FAQs
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- User Manuals