Colon

Synaptophysin (Dako Omnis)

Clone DAK-SYNAP

Synaptophysin is a 38 kDa membrane glycoprotein expressed in neuroendocrine cells and neurons involved in transmission via synaptic vehicles.

Results aid in the classification of neuroendocrine neoplasms, such as neuroendocrine lung tumors (e.g. carcinoid, atypic carcinoid, SCLC, LCNEC and non-small cell lung cancer), neuroendocrine tumors of the gastroenteropancreatic tract, e.g. neuroendocrine tumors (NETs), neuroendocrine carcinoma (NECs) and other epithelial neuroendocrine neoplasms such as pituitary adenomas, medullary thyroid carcinoma and parathyroid adenomas.

Clone DAK-SYNAP is raised against a recombinant immunogen corresponding to the C-terminal cytoplasmic domain of human synaptophysin.

Monoclonal Mouse Anti-Human

Features

Optimized staining performance of both high and low-expression structures
Dako Omnis and the dynamic gap staining technology provides a consistent, uniform staining with excellent morphology
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis
The staining performance of all FLEX RTU antibodies has been defined, tested and approved through collaboration with leading, international pathology experts.

Specifications


Application	Formalin HIER
Clone	DAK-SYNAP
Code Number	GA660
Immunogen	A recombinant protein fragment corresponding to the C-terminal cytoplasmic domain of human synaptophysin.
Isotype	IgG1, kappa
Reagent Provided	Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions	Dako Omnis
Species	Anti-Human
Specificity	In Western blot analysis of human neuroblastoma cell lysate, the antibody labels a major band at 40 kDa corresponding to the expected molecular weight of synaptophysin.

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Featured References

Product Description References: 1. Wiedenmann B, Franke WW. Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell 1985,40:1017-28.
2. Kwon SE, Chapman ER. Synaptophysin regulates the kinetics of synaptic vesicle endocytosis in central neurons. Neuron 2011:70:847-85.

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Synaptophysin (Dako Omnis)

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