This monoclonal mouse antibody reacts with human progesterone receptor (PR), a steroid hormone receptor that plays an important role in breast cancer. Historical studies have shown that estrogen receptor (ER) and PR status is correlated with untreated outcome (i.e. prognostic for well-differentiated invasive breast cancer) and with response to anti-hormonal therapy (1). Generally, the absence of ER and PR may indicate early recurrence and poor survival of breast cancer patients, while the presence of ER and PR in breast tumors may indicate potential benefit from tamoxifen and other anti-hormonal therapies. The antibody may be used in the semi-quantitative detection of human progesterone receptor in tissue sections of human breast cancer by immunohistochemistry.
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Product Details
Features
Optimized staining performance of both high and low-expression structures
Dako Omnis and the dynamic gap staining technology provides a consistent, uniform staining with excellent morphology
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis
The staining performance of all FLEX RTU antibodies has been defined, tested and approved through collaboration with leading, international pathology experts.
Specifications
Application
Formalin
HIER
Clone
PgR 1294
Code Number
GA090
Immunogen
Formalin-fixed recombinant full-length A-form of human progesterone receptor (12). See package insert for reference(s).
Isotype
IgG1, kappa
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions
Dako Omnis
Species
Mouse Anti-Human
Specificity
Anti-PR, PgR 1294 has been demonstrated to react with the PR-A and PR-B forms by Western blot of whole cell extracts and reacts with both free and hormone-bound PR (12). The epitope has been mapped to the amino terminal domain shared by PR-A and PR-B. See package insert for reference(s).