Embryonal carcinoma

Octamer-Binding Transcription Factor 3/4 (Autostainer Link 48)

Clone N1NK

Octamer-binding transcription factor 3/4 (OCT3/4) is expressed in early embryonic cells and germ cells and is central to the gene regulatory network responsible for self-renewal, pluripotency, and lineage commitment in embryonic stem cells and induced pluripotent stem cells (1).

Antibodies to OCT3/4 may be a useful aid for classification of specific subtypes of germ cell tumors including seminoma, embryonal carcinoma and intratubular germ cell neoplasia of unclassified type (IGCNU) (2, 3).

Monoclonal Mouse Anti-Human

Features

Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

Specifications


Application	Formalin HIER
Clone	N1NK
Code Number	IR092
Immunogen	Recombinant protein corresponding to 147 amino acids at N-terminus of human OCT3/4.
Isotype	IgG1, kappa
Reagent Provided	Monoclonal mouse antibody provided in liquid form as cell culture supernatant in 0.05 mol/L Tris-HCl, 0.015 mol/L sodium azide, pH 7.2. This product contains stabilizing protein.
Solutions	Autostainer Link 48
Species	Mouse Anti-Human
Specificity	In Western blotting of hES-TW1 cell lysates, Anti-OCT3/4, clone N1NK recognizes a major band of ~40 kDa corresponding to the expected molecular weight of OCT3/4 (9).

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Featured References

Product Description References: 1. Bhartiya D, Kasiviswanathan S, Unni SK, Pethe P, Dhabalia J, Patwardhan S, et al. Newer insights into premeiotic development of germ cells in adult human testis using Oct-4 as a stem cell marker. J Histochem Cytochem 2010,58:1093-1106.
2. Cheng L. Establishing a germ cell origin for metastatic tumors using OCT4 immunohistochemistry. Cancer 2004,101:2006-10.
3. Jones TD, Ulbright TM, Eble JN, Cheng L. OCT4: a sensitive and specific biomarker for intratubular germ cell neoplasia of the testis. Clin Cancer Res 2004,10:8544-7.

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Octamer-Binding Transcription Factor 3/4 (Autostainer Link 48)

Product Details

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