Mismatch repair gene hMLH1 is a ubiquitous gene encoding the mismatch repair protein (MMR) known as MutL protein homolog 1 (MLH1). MLH1 is utilized by normal proliferating cells to repair point mutations that may occur during DNA replication. Antibodies to MLH1 are a useful aid for classification of colorectal cancer.
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Product Details
Features
Optimized staining performance of both high and low-expression structures
Dako Omnis and the dynamic gap staining technology provides a consistent, uniform staining with excellent morphology
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis
The staining performance of all FLEX RTU antibodies has been defined, tested and approved through collaboration with leading, international pathology experts.
Specifications
Application
Formalin
HIER
Clone
ES05
Code Number
GA079
Form/Configuration
Ready-to-Use, FLEX
Immunogen
Recombinant protein corresponding to a 210 amino acid portion of the human MLH1 molecule.
Isotype
IgG1, kappa
Reagent Provided
Ready-to-use monoclonal antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide
Solutions
Dako Omnis
Species
Mouse Anti-Human
Specificity
In Western blotting of human Caco-2 cell lysate, the antibody labels a major band at 88 kDa corresponding to the expected molecular weight of MLH1.