Reacts with sialylated Lea-active pentasaccharide (sialylated lacto-N-fucopentaose II) which is enzymatically synthesized by sialylation of type 1 carbohydrate chains. The CA 19-9 antigen has been immunohistochemically demonstrated in ductal epithelium of the breast, kidney, salivary glands and sweat glands. The antibody reacts with epithelium of the lung and the colon, pancreatic acini and ducts, biliary epithelium in the liver and ductal epithelium of the prostate. Results aid in the classification of gastrointestinal carcinomas, including adenocarcinomas of the stomach, intestine, and pancreas.
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Product Details
Features
Excellent specificity
High lot to lot consistency
Optimized for immunohistochemistry (IHC) with validated protocols
Certified manufacturing facilities guarantee full quality control
More than 50 years experience ensuring quality and innovation in antibodies and reagents
Specifications
Application
Formalin
Clone
1116-NS-19-9
Code Number
M3517
Immunogen
Human colon carcinoma cell line SW1116 (1). See package insert for reference(s).
Isotype
IgG1, kappa
Reagent Provided
Monoclonal mouse antibody provided in liquid form as purified tissue culture supernatant in 0.05 mol/L Tris-HCl, pH 7.6 and 0.015 mol/L sodium azide. This product contains stabilizing protein.
Solutions
Concentrate
Species
Mouse Anti-Human
Specificity
Monoclonal antibody to CA 19-9 reacts with the sialylated Lea-active pentasaccharide (sialylated lacto-N-fucopentaose II) which is enzymatically synthesized by sialylation of type-1 carbohydrate chains (2). Anti-CA 19-9 recognizes the sialic acid-containing residue of the monosialoganglioside (3). Removal of the sialic acid residue by neuraminidase treatment of tissue, eliminates positive immunoreactivity with anti-CA 19-9 (4). Sialyl Lea is synthesized from type 1 blood group precursor chains and is present in individuals expressing the Lea and/or Leb blood group antigens (5). See package insert for reference(s).
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