Beta-catenin is an 88 kDa multifunctional protein playing an essential role in cell-cell adhesion by binding to the transmembrane protein, cadherin. Beta-catenin is also involved in the regulation of gene expression as a mediator of the Wnt signaling pathway. The expression and intracellular localization of beta-catenin is altered in many types of cancers.
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Product Details
Features
Optimized staining performance of both high and low-expression structures
Dako Omnis and the dynamic gap staining technology provides a consistent, uniform staining with excellent morphology
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis
The staining performance of all FLEX RTU antibodies has been defined, tested and approved through collaboration with leading, international pathology experts.
Specifications
Application
Formalin
HIER
Clone
β-Catenin-1
Code Number
GA702
Immunogen
Recombinant C-terminal ß-catenin fusion protein (6). See package insert for reference(s).
Isotype
IgG1, kappa
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions
Dako Omnis
Species
Mouse Anti-Human
Specificity
In Western blotting of human epithelial A431 cells the antibody labels a band corresponding to human ß-catenin protein. No cross-reactivity with α and γ-catenin was observed (6). See package insert for reference(s).