GenetiSure Pre-Screen Microarrays
The GenetiSure Pre-Screen microarray screens for DNA copy number variations and chromosomal aneuploidies in human cell samples collected from embryo biopsies and single cell samples. The system takes advantage of Agilent’s dual-color CGH technology and uses a specific protocol that allows sample vs sample hybridization and analysis against both male and female reference samples for optimal results.
The microarrays have uniform, genome-wide probe coverage, with increased density on chromosomes 13, 18, 20, 21, 22 and X. These are the chromosomes associated with aneuploidy events, allowing sample-to-results in less than 24 hours. The complete kit solution includes the new amp and labeling bundle and all components needed to amplify and label up to 48 single-cell samples to maximize workflow efficiency with any throughput. A single cell aneuploidy detection workflow is also included in CytoGenomics software.
The microarrays have uniform, genome-wide probe coverage, with increased density on chromosomes 13, 18, 20, 21, 22 and X. These are the chromosomes associated with aneuploidy events, allowing sample-to-results in less than 24 hours. The complete kit solution includes the new amp and labeling bundle and all components needed to amplify and label up to 48 single-cell samples to maximize workflow efficiency with any throughput. A single cell aneuploidy detection workflow is also included in CytoGenomics software.
For Research Use Only. Not for use in diagnostic procedures.
Product Details
Features
- Increased density on chromosomes 13, 18, 20, 21, 22 and X enables sample-to-results in less than 24 hours
- High resolution screening to detect genomic aberrations down to 5Mb using the Single Cell Recommended Analysis Method, and as low as 1Mb using the Single Cell Small Aberration Method.
- Rapid identification of aneuploidies and copy number from samples with few cells like Blastomere (Day 3) or Trophectoderm (Day 5)
- A powerful single cell aneuploidy detection analysis workflow is included in CytoGenomics software.
- Efficient protocol enables processing up to 48 samples in less than 8h
- Amplification & labeling bundle with reagents included to process catalog or custom array formats
- Cost-effective screening from 6 or 14 samples/ experiment run (4x180K or 8x60K slide respectively)
- Probes are annotated against NCBI Build 38 (UCSC GRCh38, Dec. 2013)
Featured References
- Publications
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- Pinto D et al. Comprehensive assessment of array-based platforms and calling algorithms for detection of copy number variants. Nat Biotechnol. 2011 May 8;29(6):512-20. doi: 10.1038/nbt.1852 [Application: General] Learn More
- Alesi V et al. Easychip 8x15k: A New Tool for Detecting Chromosome Anomalies in Low Risk Pregnancies, Supporting and Integrating Standard Karyotype J Genet Syndr Gene Ther 7: 277. doi:10.4172/2157-7412.1000277 [Application: Prenatal] Learn More
- Chau MHK et al. Characteristics and mode of inheritance of pathogenic copy number variants in prenatal diagnosis. Am J Obstet Gynecol. 2019 Nov;221(5):493.e1-493.e11. doi: 10.1016/j.ajog.2019.06.007. Epub 2019 Jun 14. [Application: Prenatal] Learn More
