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Agilent VeriPulse enables fully automated NMR system calibration, maintenance, and optimization
By Paul Bowyer
Agilent NMR Applications Scientist
Historically, Nuclear Magnetic Resonance (NMR) spectrometers have required experienced users to devote hours of time to regularly measure system performance. Additionally, these users had to manually optimize the shim values to maintain optimal system performance. Keeping an NMR system at the operational level needed to meet installation specification tests required in-depth user training and hands-on experience. With the Agilent VeriPulse system optimization package, anyone can easily verify that the Agilent ProPulse and 400-MR NMR systems are performing as designed.
VeriPulse is a new feature of Agilent VnmrJ 4.1 software, which comes standard with the new Agilent ProPulse NMR System and 400-MR NMR Spectrometers.
Shimming the magnetic field gradients - now fully automated
One of the fundamental requirements for optimal NMR performance is that the magnetic field surrounding the sample be homogeneous to within a few parts per billion. The most important system specification tests are predicated on having excellent magnetic field homogeneity (Figure 1). This is accomplished by adjusting the currents in the shim gradient coils. While many methods have been developed to help users perform this task in a fast and simple manner, it has always required expert-level attention and hours of manual shimming for the system to meet performance specifications.
With the introduction of VeriPulse, Agilent has moved system testing and qualification into a fully automated and routine process. Users simply select the desired tests and desired targets for those tests (Figure 2) and the system does all the work, reliably and reproducibly meeting all system test specifications, at any time.
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Figure 1. This spectrum shows the actual shimming results returned by Agilent VeriPulse after fully automated shim optimization (all shim gradients had been zeroed prior to the start of this test). The results demonstrate the power of VeriPulse shimming algorithms.
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Figure 2. VeriPulse allows selection and submission of an extensive range of system calibrations and performance tests from within an intuitive and easy-to-use interface. All system optimization and testing steps are then performed automatically.
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Figure 3. Agilent VeriPulse automated results reporting. All system tests, with targets and experimental results, are reported in a clean and easy-to-read system test report.
Specification reporting - ideal for system performance tracking
Once Agilent VeriPulse completes data system optimization and data collection, the test results are delivered using a simple and clear test report (Figure 3). The report shows which tests were performed, together with a target and result for each test, and clear notification of whether the test passed. This test report can be used as the basis for a complete system testing and qualification program that users can repeat at will.
Agilent NMR - simply better
Agilent’s VnmrJ 4.1 software featuring VeriPulse brings the power of NMR to researchers of all types and all skill levels.
- Confidence in results: Agilent VeriPulse keeps the system optimized and proves it
- Automated calibration and testing: Verifies system functionality
- Automated 3D shimming: Maintains the highest quality spectral output
- Unrivaled ease-of-use and reliability: Lets you focus your time on your science
For more in-depth information on VeriPulse, register to attend a live webinar on Tuesday March 11. Learn more about Agilent’s newest NMR technologies and applications at our ENC User Meeting and exhibit booth at the 55th annual Experimental Nuclear Magnetic Resonance Conference, March 23–28, 2014 in Boston, MA.
Agilent is committed to improving the entire NMR user experience. See how Agilent brings true ease-of-use to high-performance NMR in this video overview of the Agilent ProPulse NMR System. Discover the complete line of Agilent NMR solutions that can be used to analyze both small- and large-molecule compounds in research and industrial applications.
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Figure 1.
This spectrum shows the actual shimming results returned by Agilent VeriPulse after fully automated shim optimization (all shim gradients had been zeroed prior to the start of this test). The results demonstrate the power of VeriPulse shimming algorithms.
