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Doctor Dominic Hare

Iron Man

 

Agilent aids research into how essential elements can become killers

Iron, like oxygen, is essential to life. But too much can be deadly. Too much and you could end up with a neurodegenerative disease like Parkinson’s.

Scientists have long known that Parkinson’s patients have abnormally high concentrations of iron in their brains, and Dominic Hare wants to look at that more closely.

But that’s just the beginning.

Hare, who runs the Atomic Pathology Laboratory at the Florey Institute in Melbourne, is working to measure—and actually visualize—the level of iron and other essential elements in biopsies, surgical resections, and other tissue samples. To that end, he and his team are using a combination of laser ablation ICP-MS technology from Agilent and special software they have developed in-house.

Dominic Hare, PhD
Dominic Hare, PhD

Head of Atomic Pathology Laboratory
Florey Institute of Neuroscience and Mental Health
Melbourne, Australia

Selected publications

Tracing Environmental Exposure from Neurodevelopment to Neurodegeneration.
Heffernan AL, Hare DJ.
Trends Neurosci. 2018 May 7. pii: S0166-2236(18)30104-8. doi: 10.1016/j.tins.2018.04.005.

A guide to integrating immunohistochemistry and chemical imaging.
Bishop DP, Cole N, Zhang T, Doble PA, Hare DJ.
Chem Soc Rev. 2018 Jun 5;47(11):3770-3787. doi: 10.1039/c7cs00610a.

Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain.
Genoud S, Roberts BR, Gunn AP, Halliday GM, Lewis SJG, Ball HJ, Hare DJ, Double KL.
Metallomics. 2017 Oct 18;9(10):1447-1455. doi: 10.1039/c7mt00244k.

The APOE ε4 Allele Is Associated with Lower Selenium Levels in the Brain: Implications for Alzheimer's Disease.
R Cardoso B, Hare DJ, Lind M, McLean CA, Volitakis I, Laws SM, Masters CL, Bush AI, Roberts BR.
ACS Chem Neurosci. 2017 Jul 19;8(7):1459-1464. doi: 10.1021/acschemneuro.7b00014

Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS).
Hare DJ, Kysenius K, Paul B, Knauer B, Hutchinson RW, O'Connor C, Fryer F, Hennessey TP, Bush AI, Crouch PJ, Doble PA.
J Vis Exp. 2017 Jan 22;(119). doi: 10.3791/55042.

Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex
Hare DJ, Raven EP, Roberts BR, Bogeski M, Portbury SD, McLean CA, Masters CL, Connor JR, Bush AI, Crouch PJ, Doble PA.
Neuroimage. 2016 Aug 15;137:124-131. doi: 10.1016/j.neuroimage.2016.05.057.

Imaging metals in biology: balancing sensitivity, selectivity and spatial resolution.
Hare DJ, New EJ, de Jonge MD, McColl G.
Chem Soc Rev. 2015 Oct 7;44(17):5941-58.

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